Health Predispositions
Take some time to download the report examples that interest you to better understand the types of information your patients receive and may wish to share with you.
Take some time to download the report examples that interest you to better understand the types of information your patients receive and may wish to share with you.
The Health Predispositions category includes both reports that meet FDA requirements for Genetic Health Risks and reports Powered by 23andMe Research. These reports are not intended to tell a person anything about his or her current state of health, or to be used to make medical decisions.
Those with a personal or family history of any of these conditions should speak with their healthcare provider to determine if comprehensive genetic testing is appropriate.
all reports with this icon focus on heart health.
all reports with this icon focus on sleep quality.
Each Genetic Health Risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. These reports are not intended to tell a person anything about his or her current state of health, or to be used to make medical decisions, including whether or not he or she should take a medication or how much of a medication should be taken.
Genetic Health Risk reports package insert
White Paper 23-15: Scientific Standards for 23andMe’s Health and Trait Reports
Variant(s) detected
Your patient has one or more of the variants we tested. They may be at increased risk for the condition based on this result. This doesn’t mean s/he will definitely develop the condition. Other factors may also affect their risk.
Result not determined
Your patient’s test result could not be determined. This can be caused by random test error or other factors that interfere with the test.
| Report | Gene | Variants | Best Studied Ethnicities |
|---|---|---|---|
| Report | GeneCFH, ARMS2 | Variants2 | Relevant Ethnicities All ethnicities but best studied in Europeans |
| Report | GeneSERPINA1 | Variants2 | Relevant Ethnicities European |
| Report | GeneBRCA1, BRCA2 | Variants44 | Relevant Ethnicities Ashkenazi Jewish, plus some variants more common in African American, European, Hispanic/Latino, and Asian |
| Report | GeneHLA-DQA1, HLA-DQB1 | Variants2 | Relevant Ethnicities All ethnicities but best studied in Europeans |
| Report | GeneAPOL1 | Variants2 | Relevant Ethnicities African/African American |
Report
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GeneLDLR, APOB | Variants24 | Relevant Ethnicities European, Lebanese, Old Order Amish |
| Report | GeneG6PD | Variants2 | Relevant Ethnicities African, Southern European, Kurdish Jewish, Middle Eastern, Central Asian, South Asian descent |
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Report
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GeneTTR | Variants3 | Relevant Ethnicities African American, West African, Portuguese, Japanese, Northern Swedish, Irish, British |
| Report | GeneHFE | Variants2 | Relevant Ethnicities European |
| Report | GeneHOXB13 | Variants1 | Relevant Ethnicities European |
| Report | GeneF2, F5 | Variants2 | Relevant Ethnicities European |
| Report | GeneAPOE | Variants1 | Relevant Ethnicities European |
| Report | GeneMUTYH | Variants2 | Relevant Ethnicities Northern European |
| Report | GeneLRRK2, GBA | Variants2 | Relevant Ethnicities European, Ashkenazi Jewish, North African Berber |
Reports that are “Powered by 23andMe Research” are developed using data and insights gathered from thousands of customers who consented to participate in our research.
White Paper 23-19: The Science Behind 23andMe’s Type 2 Diabetes Report
White Paper 23-21: A Generalized Method for the Creation and Evaluation of Polygenic Scores
| POLYGENIC REPORTS | VARIANTS CONTRIBUTING TO MODEL | RELEVANT ETHNICITIES |
|---|---|---|
| Report Anxiety | Variants19,000+ | Relevant Ethnicities East/Southeast Asian, South Asian, European, Hispanic/Latino, Northern African/Western Asian, Sub-Saharan African/African American |
| Report Asthma | Variants24,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American |
|
Report
Atrial Fibrillation
|
Variants2000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Bipolar Disorder | Variants16,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Sub-Saharan African/African American |
| Report Breast Cancer | Variants2,700+ | Relevant Ethnicities East/Southeast Asian, South Asian, European, Hispanic/Latino, Northern African/Western Asian, Sub-Saharan African/African American |
| Report Colorectal Cancer | Variants1,700+ | Relevant Ethnicities European, Hispanic/Latino |
|
Report
Coronary Artery Disease
|
Variants2000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Diverticulitis | Variants19,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Central and Western Asian descent, South Asian, Sub-Saharan African/African American |
| Report Eczema (Atopic Dermatitis) | Variants2100+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Fibromyalgia | Variants13,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American |
| Report Gallstones | Variants6900+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Gestational Diabetes | Variants6000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Glaucoma | Variants21,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American |
| Report Gout | Variants21,000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Hashimoto’s Disease | Variants11,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American |
| Report HDL Cholesterol | Variants15,800+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
|
Report
High Blood Pressure
|
Variants2000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Insomnia | Variants28,000+ | Relevant Ethnicities East/Southeast Asian, European, Northern African/Western Asian, South Asian, Hispanic/Latino, Sub-Saharan African/African American |
| Report Irritable Bowel Syndrome | Variants27,000+ | Relevant Ethnicities East/Southeast Asian, European, Northern African/Central and Western Asian, South Asian, Sub-Saharan African/African American, Hispanic/Latino |
| Report Kidney Stones | Variants20,000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
|
Report
LDL Cholesterol
|
Variants2000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Lupus | Variants26,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Central & Western Asian (Middle Eastern), South Asian, Sub-Saharan African/African American |
| Report Migraine | Variants20,000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Nonalcoholic Fatty Liver Disease | Variants1400+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Obstructive Sleep Apnea | Variants23,000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Panic Attacks | Variants40,000+ | Relevant Ethnicities European, Hispanic/Latino, Sub-Saharan African/African American, South Asian and East/Southeast Asian descent |
| Report Polycystic Ovary Syndrome | Variants1300+ | Relevant Ethnicities European, Hispanic/ Latino, East/Southeast Asian, South Asian, Sub-Saharan African/ African American, Northern African/Central and Western Asian descent |
| Report Preeclampsia | Variants14,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American |
| Report Prostate Cancer | Variants4,700+ | Relevant Ethnicities East/Southeast Asian, South Asian, European, Hispanic/Latino, Northern African/Western Asian, Sub-Saharan African/African American |
| Report Psoriasis | Variants7,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American |
| Report Restless Legs Syndrome | Variants23,000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Rosacea | Variants14,000+ | Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American |
| Report Severe Acne | Variants8500+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
| Report Skin Cancer (Basal and Squamous Cell Carcinomas) | Variants11,000+ | Relevant Ethnicities European, Hispanic/Latino, Northern African/Western Asian, Sub-Saharan African/African American |
| Report Skin Cancer (Melanoma) | Variants1,800+ | Relevant Ethnicities European, Hispanic/Latino, Northern African/Western Asian |
| Report Triglycerides | Variants7400+ | Relevant Ethnicities European, Hispanic/ Latino, East/Southeast Asian, South Asian, Sub-Saharan African/ African American, Northern African/Central and Western Asian descent |
|
Report
Type 2 Diabetes
|
Variants1000+ | Relevant Ethnicities European, Hispanic/Latino, African, East Asian, South Asian |
| Report Uterine Fibroids | Variants1000+ | Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent |
*The 23andMe PGS test includes health predisposition and carrier status reports. Health predisposition reports include both reports that meet US FDA requirements for genetic health risks and the 23andMe Type 2 Diabetes health predisposition report which is based on 23andMe research and has not been reviewed by the FDA. The test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child’s risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. Warnings & Limitations: The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of the 185delAG and 5382insC variants in the BRCA1 gene and the 6174delT variant in the BRCA2 gene. The report describes if a woman is at increased risk of developing breast and ovarian cancer, and if a man is at increased risk of developing breast cancer or may be at increased risk of developing prostate cancer. The three variants included in this report are most common in people of Ashkenazi Jewish descent and do not represent the majority of BRCA1/BRCA2 variants in the general population. The MUTYH-Associated Polyposis Genetic Health Risk Report is indicated for reporting the Y179C and G396D variants in the MUTYH gene and an increased risk for colorectal cancer. The two variants included in this report are most common in people of Northern European descent. These reports do not include variants in other genes linked to hereditary cancers and the absence of variants included in these reports do not rule out the presence of other genetic variants that may impact cancer risk. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed in a clinical setting before taking any medical action. For important information and limitations regarding other genetic health risk reports and carrier status reports, visit 23andme.com/test-info.
The 23andMe PGS test uses qualitative genotyping to detect 6 variants in 3 genes in the genomic DNA of adults from saliva for the purpose of reporting and interpreting information about the processing of certain therapeutics to inform discussions with a healthcare professional. It does not describe if a person will or will not respond to a particular therapeutic and does not describe the association between detected variants and any specific therapeutic. Results should be confirmed in a clinical setting with independent genetic testing before taking any medical action. Warning: Test information should not be used to start, stop, or change any course of treatment and does not test for all possible variants that may affect metabolism or protein function. The PGS test is not a substitute for visits to a healthcare professional. Making changes to your current regimen can lead to harmful side effects or reduced intended benefits of your medication, therefore consult with your healthcare professional before taking any medical action. For a complete list of the 6 variants tested, visit https://permalinks.23andme.com/pdf/pgt_product_info_page_21jan2020.pdf.
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