Health Predispositions

Take some time to download the report examples that interest you to better understand the types of information your patients receive and may wish to share with you.

Health Predispositions

The Health Predispositions category includes both reports that meet FDA requirements for Genetic Health Risks and reports Powered by 23andMe Research. These reports are not intended to tell a person anything about his or her current state of health, or to be used to make medical decisions.

Those with a personal or family history of any of these conditions should speak with their healthcare provider to determine if comprehensive genetic testing is appropriate.

Heart Health all reports with this icon focus on heart health.

Sleep Quality all reports with this icon focus on sleep quality.

Genetic Health Risks

Each Genetic Health Risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. These reports are not intended to tell a person anything about his or her current state of health, or to be used to make medical decisions, including whether or not he or she should take a medication or how much of a medication should be taken.

Genetic Health Risk reports package insert

White Paper 23-15: Scientific Standards for 23andMe’s Health and Trait Reports

Possible test results
Report Gene Variants Best Studied Ethnicities
Report Age-Related Macular Degeneration GeneCFH, ARMS2 Variants2 Relevant Ethnicities All ethnicities but best studied in Europeans
Report Alpha-1 Antitrypsin Deficiency GeneSERPINA1 Variants2 Relevant Ethnicities European
Report BRCA1/BRCA2 (Selected Variants) GeneBRCA1, BRCA2 Variants44 Relevant Ethnicities Ashkenazi Jewish, plus some variants more common in African American, European, Hispanic/Latino, and Asian
Report Celiac Disease GeneHLA-DQA1, HLA-DQB1 Variants2 Relevant Ethnicities All ethnicities but best studied in Europeans
Report Chronic Kidney Disease (APOL1-Related) GeneAPOL1 Variants2 Relevant Ethnicities African/African American
Heart Health Report Familial Hypercholesterolemia GeneLDLR, APOB Variants24 Relevant Ethnicities European, Lebanese, Old Order Amish
Report G6PD Deficiency GeneG6PD Variants2 Relevant Ethnicities African, Southern European, Kurdish Jewish, Middle Eastern, Central Asian, South Asian descent
Heart Health Report Hereditary Amyloidosis (TTR-Related) GeneTTR Variants3 Relevant Ethnicities African American, West African, Portuguese, Japanese, Northern Swedish, Irish, British
Report Hereditary Hemochromatosis (HFE-Related) GeneHFE Variants2 Relevant Ethnicities European
Report Hereditary Prostate Cancer (HOXB13-Related) GeneHOXB13 Variants1 Relevant Ethnicities European
Report Hereditary Thrombophilia GeneF2, F5 Variants2 Relevant Ethnicities European
Report Late-Onset Alzheimer’s Disease GeneAPOE Variants1 Relevant Ethnicities European
Report MUTYH-Associated Polyposis GeneMUTYH Variants2 Relevant Ethnicities Northern European
Report Parkinson’s Disease GeneLRRK2, GBA Variants2 Relevant Ethnicities European, Ashkenazi Jewish, North African Berber

Powered by 23andMe Research

Reports that are “Powered by 23andMe Research” are developed using data and insights gathered from thousands of customers who consented to participate in our research.

White Paper 23-19: The Science Behind 23andMe’s Type 2 Diabetes Report

White Paper 23-21: A Generalized Method for the Creation and Evaluation of Polygenic Scores

POLYGENIC REPORTS VARIANTS CONTRIBUTING TO MODEL RELEVANT ETHNICITIES
Report Anxiety Variants19,000+ Relevant Ethnicities East/Southeast Asian, South Asian, European, Hispanic/Latino, Northern African/Western Asian, Sub-Saharan African/African American
Report Asthma Variants24,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American
Heart Health Report Atrial Fibrillation Variants2000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Heart Health Report Coronary Artery Disease Variants2000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Diverticulitis Variants19,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Central and Western Asian descent, South Asian, Sub-Saharan African/African American
Report Eczema (Atopic Dermatitis) Variants2100+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Fibromyalgia Variants13,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American
Report Gallstones Variants6900+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Gestational Diabetes Variants6000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Glaucoma Variants21,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American
Report Gout Variants21,000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Hashimoto’s Disease Variants11,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American
Report HDL Cholesterol Variants15,800+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Heart Health Report High Blood Pressure Variants2000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Insomnia Variants28,000+ Relevant Ethnicities East/Southeast Asian, European, Northern African/Western Asian, South Asian, Hispanic/Latino, Sub-Saharan African/African American
Report Irritable Bowel Syndrome Variants27,000+ Relevant Ethnicities East/Southeast Asian, European, Northern African/Central and Western Asian, South Asian, Sub-Saharan African/African American, Hispanic/Latino
Report Kidney Stones Variants20,000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Heart Health Report LDL Cholesterol Variants2000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Lupus Variants26,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Central & Western Asian (Middle Eastern), South Asian, Sub-Saharan African/African American
Report Migraine Variants20,000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Nonalcoholic Fatty Liver Disease Variants1400+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Obstructive Sleep Apnea Variants23,000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Panic Attacks Variants40,000+ Relevant Ethnicities European, Hispanic/Latino, Sub-Saharan African/African American, South Asian and East/Southeast Asian descent
Report Polycystic Ovary Syndrome Variants1300+ Relevant Ethnicities European, Hispanic/ Latino, East/Southeast Asian, South Asian, Sub-Saharan African/ African American, Northern African/Central and Western Asian descent
Report Preeclampsia Variants14,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American
Report Psoriasis Variants7,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American
Report Restless Legs Syndrome Variants23,000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Rosacea Variants14,000+ Relevant Ethnicities East/Southeast Asian, European, Hispanic/Latino, Northern African/Western Asian, South Asian, Sub-Saharan African/African American
Report Severe Acne Variants8500+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent
Report Skin Cancer (Basal and Squamous Cell Carcinomas) Variants11,000+ Relevant Ethnicities European, Hispanic/Latino, Northern African/Western Asian, Sub-Saharan African/African American
Report Skin Cancer (Melanoma) Variants1,800+ Relevant Ethnicities European, Hispanic/Latino, Northern African/Western Asian
Report Triglycerides Variants7400+ Relevant Ethnicities European, Hispanic/ Latino, East/Southeast Asian, South Asian, Sub-Saharan African/ African American, Northern African/Central and Western Asian descent
Heart Health Report Type 2 Diabetes Variants1000+ Relevant Ethnicities European, Hispanic/Latino, African, East Asian, South Asian
Report Uterine Fibroids Variants1000+ Relevant Ethnicities European, Hispanic/Latino, East/Southeast Asian, South Asian, Sub-Saharan African/African American, Northern African/Central and Western Asian descent

FAQ

Questions? Contact us at medical@23andme.com.

*The 23andMe PGS test includes health predisposition and carrier status reports. Health predisposition reports include both reports that meet US FDA requirements for genetic health risks and the 23andMe Type 2 Diabetes health predisposition report which is based on 23andMe research and has not been reviewed by the FDA. The test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child’s risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. Warnings & Limitations: The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of the 185delAG and 5382insC variants in the BRCA1 gene and the 6174delT variant in the BRCA2 gene. The report describes if a woman is at increased risk of developing breast and ovarian cancer, and if a man is at increased risk of developing breast cancer or may be at increased risk of developing prostate cancer. The three variants included in this report are most common in people of Ashkenazi Jewish descent and do not represent the majority of BRCA1/BRCA2 variants in the general population. The MUTYH-Associated Polyposis Genetic Health Risk Report is indicated for reporting the Y179C and G396D variants in the MUTYH gene and an increased risk for colorectal cancer. The two variants included in this report are most common in people of Northern European descent. These reports do not include variants in other genes linked to hereditary cancers and the absence of variants included in these reports do not rule out the presence of other genetic variants that may impact cancer risk. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed in a clinical setting before taking any medical action. For important information and limitations regarding other genetic health risk reports and carrier status reports, visit 23andme.com/test-info.

The 23andMe PGS test uses qualitative genotyping to detect 6 variants in 3 genes in the genomic DNA of adults from saliva for the purpose of reporting and interpreting information about the processing of certain therapeutics to inform discussions with a healthcare professional. It does not describe if a person will or will not respond to a particular therapeutic and does not describe the association between detected variants and any specific therapeutic. Results should be confirmed in a clinical setting with independent genetic testing before taking any medical action. Warning: Test information should not be used to start, stop, or change any course of treatment and does not test for all possible variants that may affect metabolism or protein function. The PGS test is not a substitute for visits to a healthcare professional. Making changes to your current regimen can lead to harmful side effects or reduced intended benefits of your medication, therefore consult with your healthcare professional before taking any medical action. For a complete list of the 6 variants tested, visit https://permalinks.23andme.com/pdf/pgt_product_info_page_21jan2020.pdf.